licofelone: a novel non-steriodal anti-inflammatory drug (nsaid) in arthritis

نویسندگان

k.m. manjanna

b. shivakumar

چکیده

arthritis refers to different medical conditions associated with disorder of the primary structures that determine joint functions such as bones, cartilage and synovial membranes. drug discovery and delivery to retard the degeneration of joint tissues are challenging. current treatments of different arthritis involves administration of ideal non-steroidal anti-inflammatory drugs (nsaids) but are frequently associated with adverse reactions, related to inhibition of cyclo-oxygenase (cox) in tissues where prostaglandins exert physiological effects, such as gastric mucosal defense and renal homeostasis. as a consequence, the interest for novel approaches has re-emerged. new therapeutic options, still under clinical evaluation, are represented as dual cox and 5-lipooxygenase (5-lox) inhibitors. these are expected to possess clinical advantages over the selective inhibitors of cox enzyme. one of the most promising compounds belonging to this category, licofelone, a competitive inhibitor of 5-lipoxygenase, cyclooxygenase (cox-1 and cox-2), is currently in clinical development for the treatment of osteoarthritis (oa). licofelone decreases the production of pro-inflammatory leukotrienes and prostaglandins which are involved in the pathophysiology of oa and in gastrointestinal (gi) damage induced by nsaids and have the potential to combine good analgesic and anti-inflammatory effects with excellent gi tolerability. the emerging clinical data for licofelone indicate that it is an effective and well-tolerated therapy which could be suitable for the long-term treatment of patients with oa. this review focuses upon the gastrointestinal (gi) safety of selective cox-2 inhibitors and of novel therapeutic strategies, in comparison with traditional nsaids.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Licofelone: A Novel Non-Steriodal Anti-Inflammatory Drug (NSAID) in Arthritis

Arthritis refers to different medical conditions associated with disorder of the primary structures that determine joint functions such as bones, cartilage and synovial membranes. Drug discovery and delivery to retard the degeneration of joint tissues are challenging. Current treatments of different arthritis involves administration of ideal non-steroidal anti-inflammatory drugs (NSAIDs) but ar...

متن کامل

Licofelone: A Novel Non-Steriodal Anti-Inflammatory Drug (NSAID) in Arthritis

Arthritis refers to different medical conditions associated with disorder of the primary structures that determine joint functions such as bones, cartilage and synovial membranes. Drug discovery and delivery to retard the degeneration of joint tissues are challenging. Current treatments of different arthritis involves administration of ideal non-steroidal anti-inflammatory drugs (NSAIDs) but ar...

متن کامل

Non-Steroidal Anti-Inflammatory Drug (NSAID)-Induced Small Intestinal Injury

Nonsteroidal anti-inflammatory drugs (NSAIDs), including lowdose aspirin, are among the most widely prescribed medications, with approximately 30 million patients worldwide ingesting NSAID [1]. NSAID could cause small intestinal injury. It became clear from the studies of post-mortem samplesby Bjarnason and colleagues (1993) that NSAID use is alsoassociated with significant damage to the more d...

متن کامل

Controversies and advances in non-steroidal anti-inflammatory drug (NSAID) analgesia in chronic pain management.

Chronic pain can lead to significant disability with social and economic implications in the community. Traditional non-steroidal anti-inflammatory drugs (NSAIDs) have been part of the management of chronic pain. The risk of adverse events with traditional NSAIDs has led to the development of alternative therapeutic options. Differential blockade of the enzymes involved in pain and inflammation...

متن کامل

gastric and duodenal ulcers . anti - inflammatory drug ( NSAID ) associated

SIR,-The role of altered colonic detoxification mechanisms in various pathophysiological conditions including ulcerative colitis and carcinogenesis cannot be overemphasised. 2 We have thus read with great interest the recent report of Ramakrishna et al about sulphation as a mechanism ofphenolic compound inactivation in human colonocytes (Gut 1991; 32: 46-9). Though the work provides valuable ne...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmacology and therapeutics

جلد ۱۰، شماره ۲، صفحات ۸۲-۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023